文章信息/Info

Title:

Nano�睤rugs and Gene Delivery System Based on Cyclodextrins

作者:

鄭姣妮1; 廖榮強1; 2; 楊波2

1. 重慶市急救醫療中心 重慶大學附屬中心醫院 重慶市第四人民醫院藥劑科，重慶 400014

2. 昆明理工大學生命科學與技術學院，云南 昆明 650500

Author(s):

ZHENG Jiaoni1; LIAO Rongqiang1;  2; YANG Bo2

1. Chongqing Emergency Medical Center, Chongqing University Center Hospital,Department of Pharmacy, Chongqing Fourth People�餾 Hospital, Chongqing 400014, China

2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China

關鍵詞:

環糊精; 自組裝; 納米藥物; 基因載體

Keywords:

cyclodextrins;  self�瞐ssembly;  nano�瞕rugs;  gene vector

DOI:

10.7502/j.issn.1674-3962.2019.02.09

文獻標志碼:

A

摘要:

隨著納米技術與精準醫學的不斷發展，納米藥物與基因載體已被廣泛應用于腫瘤等相關疾病的治療。納米技術不但能提高藥物生物利用度，而且可以降低藥物毒副作用，這對于開發新型藥物制劑具有重要的意義。構筑納米藥物與基因載體的手段多種多樣，自組裝方法是目前最常用的手段之一。利用自組裝可以構筑出具有新型結構與功能的超分子組裝體，對探索和設計新型功能的納米藥物與基因載體具有重要的研究意義。通過環糊精自組裝來構筑納米藥物與基因載體是目前的研究熱點之一。自組裝可以避免復雜的合成步驟與純化工藝，具有方便、靈活與快捷的優勢。通過兩方面（共價偶聯方案與聚輪烷方案）介紹了基于環糊精自組裝的納米藥物與基因載體，并對其發展前景作了進一步的展望。

Abstract:

With the development of nanomedicine and precision medicine, the potential application of nano�瞕rugs and gene delivery system is gradually manifested in the field of cancer treatment. Nano technology can not only improve the bioavailability but also reduce the toxicity, which is of great significance for developing new drugs. Self�瞐ssembly supramolecular technology has been one of the hottest topics in nano biotechnology for a long time. We can take advantage of the noncovalent bond self�瞐ssembly technology to construct supramolecular assemblies with their novel structures and functions, which is of great significance for nano�瞕rug and gene carrier. Cyclodextrins are widely used in the construction of nano�瞕rug and gene carrier ascribing to their virtues of ready availability, low toxicity, self�瞐ssembly, and functional flexibility. This paper mainly introduces the nano�瞕rug and gene carrier based on cyclodextrin, some personal perspectives on this field are also presented.