文章信息/Info

Title:

Latest Research Progress of Biodegradable Magnesium Alloys in Clinical Applications

作者:

尹林; 黃華; 袁廣銀; 丁文江

上海交通大學材料科學與工程學院 輕合金精密成型國家工程研究中心，上海 200240

Author(s):

YIN Lin;  HUANG Hua;  YUAN Guangyin;  DING Wenjiang

National Engineering Research Center of Light Alloy Net Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

關(guān)鍵詞:

可降解醫(yī)用鎂合金; 骨植物器械; 血管支架; 生物相容性; 臨床應(yīng)用

Keywords:

biodegradable magnesium alloys; bone implants; cardiovascular stents; biocompatibility; clinical application

DOI:

10.7502/j.issn.1674-3962.2019.02.07

文獻標志碼:

A

摘要:

作為新一代可降解醫(yī)用金屬材料，鎂合金具有良好的力學性能、生物可降解性以及生物相容性。鎂合金用作骨修復材料時，可以有效避免應(yīng)力遮擋效應(yīng)，有利于促進骨愈合；用作血管支架材料時，可以在狹窄的血管內(nèi)經(jīng)過一段時間支架支撐和藥物治療完成正性重構(gòu)后，自行降解消失，從而降低再狹窄的風險。因此鎂合金作為可降解醫(yī)用材料具有很廣闊的臨床應(yīng)用前景，在骨內(nèi)植物器械和血管支架等領(lǐng)域有巨大的應(yīng)用潛力。首先介紹了鎂合金作為可降解醫(yī)用材料所具有的優(yōu)點以及目前所面臨的主要挑戰(zhàn)，然后分別闡述了鎂合金在骨內(nèi)植物器械和血管支架領(lǐng)域臨床應(yīng)用研究的最新進展，重點介紹了上海交通大學有關(guān)可降解醫(yī)用鎂合金的最新進展，最后總結(jié)并展望了可降解醫(yī)用鎂合金未來的發(fā)展前景。

Abstract:

Magnesium (Mg) alloys have excellent properties such as good mechanical property, biodegradation and biocompatibility, as a new generation of biodegradable metal materials. Mg alloys can avoid the stress shielding effect and promote the healing of bone for bone implants application. Mg alloys can also reduce the risk of restenosis by self�瞕egradation after a period of positive remodeling with stent support and drug treatment in the stenosis vessels for cardiovascular stent application. Therefore, Mg alloys have broad prospects for these applications. In this paper, the advantages and major challenges of Mg alloys as biodegradable materials are introduced firstly. Then, the latest research progress of biodegradable magnesium alloys in bone implants and stent applications are introduced respectively, with emphasis on the latest development of biodegradable medical magnesium alloys in Shanghai Jiao Tong University. Finally, the clinical application prospects of the biodegradable Mg alloys are discussed.