文章信息/Info

Title:

Materiobiology—Opportunities and Challenges for Bone Regenerative Biomaterials

作者:

王靖; 劉昌勝

華東理工大學 生物反應器工程國家重點實驗室 超細材料制備與應用教育部重點實驗室

Author(s):

WANG Jing;  LIU Changsheng

State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology

關鍵詞:

材料生物學; 骨修復; 微環境; 細胞; 生長因子

Keywords:

materiobiology;  bone repair;  microenvironment;  cell;  growth factor

DOI:

10.7502/j.issn.1674-3962.2019.04.05

文獻標志碼:

A

摘要:

材料與宿主微環境之間的相互作用直接影響骨修復的過程和質量。由于對材料在體內微環境中的生物學效應、修復過程及作用機理不清楚，導致目前大部分材料的修復效果不理想，難以達到真正的“骨性融合”，臨床應用受限。因此，弄清材料在骨修復過程中的生物學效應及其發生規律迫在眉睫。綜述了骨修復材料在植入體內后產生的免疫調控效應、與體內生長因子的協同效應、以及血管化效應等一些新的生物學效應，指出了材料在體內所處的環境并非靜止的，而是動態變化的，材料參數改變體內微環境，進而影響再生過程；同時，微環境也影響了材料的轉歸命運。聚焦材料生物學研究，揭示材料在生命活動中的作用機制和規律，將是未來組織修復材料的發展趨勢。

Abstract:

The interaction between materials and host microenvironment directly affects the process and quality of bone repair. Due to the unclear biological effects, repair process and mechanism of materials in the host microenvironment, the repair effects of most materials are not satisfying. It is difficult to achieve real “bony fusion”, so its clinical application is limited. Therefore, it is urgent to find out the biological effects of materials, as well as their occurring rules and mechanisms. This paper describes some novel biological effects of biomaterials after implantation into body, such as immunomodulatory effect, synergistic effect with growth factors, and angiogenesis effect. We pointed out that the implanted material exists in the dynamic host microenvironment rather than the static environment. As a result, the changes of material parameters lead to the alteration in the microenvironment, thus affecting regeneration process. On the other hand, the microenvironment also affects the fate of materials. It is suggested that the future trend of tissue regenerative materials is to focus on the study of materiobiology and reveal the mechanism and rule of materials in life activities.