文章信息/Info

Title:

Micro-Nano Scaffolds for Stem Cells and Its Clinical Application Prospects

作者:

劉鑫1; 2;  孫劍飛1; 2 ; 顧寧1; 2

1. 東南大學生物科學與醫學工程學院 江蘇省生物材料與器件重點實驗室 生物電子學國家重點實驗室
2. 蘇州納米科技協同創新中心 納米藥物與生物材料專業中心

Author(s):

LIU Xin1; 2 ; SUN JianFei1; 2 ; GU Ning1; 2

1. Jiangsu Key Laboratory for Biomaterials and Devices, State Key of Laboratory Bioeletronics, School of Biological Sciences & Medical Engineering, Southeast University
2. Collaborative Innovation Center of Suzhou Nano-Science and Technology

關鍵詞:

微納支架; 干細胞; 制備方法; 現狀; 前景

Keywords:

micro-nano scaffold;  stem cell;  preparation methods;  status;  prospects

DOI:

10.7502/j.issn.1674-3962.201810023

文獻標志碼:

A

摘要:

微納支架是一類在空間結構上具有微米或納米尺度特征的仿生支架。與傳統支架相比，微納支架具有優良的表面效應和尺寸效應，因此在多種疾病的治療中表現出極大的優異性。尤其是在與干細胞相結合后，微納支架-干細胞復合體可被廣泛應用于組織工程修復、腫瘤治療等領域。然而，微納支架的制備方法、種類、表面形貌、尺度以及內部結構序列等因素都影響著微納支架-干細胞復合體的治療效果。因此，擬從微納支架的制備方法及微納支架在干細胞治療中的研究現狀進行綜述，并對其臨床應用前景進行展望。

Abstract:

Micro-nano scaffolds are typically a type of bionic scaffold with micro- or nano-scale features structurally. Compared with traditional scaffolds, micro-nano scaffolds have excellent surface effects and size effects, and thus exhibit great superiority in the treatment of various diseases. Especially, micro-nano scaffold-stem cell complex can be widely used in tissue engineering repair, tumor treatment, and other fields when combined with stem cells. However, the preparation methods, material types, surface morphology, scale and internal structure sequence of micro-nano scaffolds are all crucial factors involved in the therapeutic effect of micro-nano scaffold-stem cell complex. Therefore, this paper intends to review the preparation of micro-nano scaffolds and the research status of micro-nano scaffolds in stem cell therapy and to prospect its clinical application.