文章信息/Info

Title:

Application of Bioactive Nanoparticles on Mesenchymal Stem Cell Therapy

作者:

張然1; 羅文亞1; 朱明盛1; 吳瑾1; 黃興祿1; 孔德領(lǐng)1; 2

1. 南開大學(xué)生命科學(xué)學(xué)院 生物活性材料教育部重點實驗室
2. 南開大學(xué) 徐榮祥再生生命科學(xué)中心

Author(s):

ZHANG Ran1;  LUO Wenya1;  ZHU Mingsheng1;  WU Jin1;  HUANG Xinglu 1;  KONG Deling1; 2

1. Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Sciences, Nankai University
2. Xu Rongxiang Center for Regenerative Life Sciences, Nankai University

關(guān)鍵詞:

納米生物活性材料; 納米顆粒; 間充質(zhì)干細胞; 治療; 示蹤

Keywords:

bioactive nanoparticles;  nanoparticles;  mesenchymal stem cells;  therapy;  tracking

DOI:

10.7502/j.issn.1674-3962.201810028

文獻標志碼:

A

摘要:

干細胞由于具有自我更新和定向分化潛能，在疾病治療中取得了重要進展，然而其治療效果還有待進一步提高。近年來，人們通過納米材料本身或負載化學(xué)小分子藥物、細胞因子、核酸藥物、多肽等組成一類具有生物活性的納米材料，以改善干細胞存活和歸巢、調(diào)控干細胞的行為、誘導(dǎo)干細胞的分化、增強干細胞的旁分泌等，從而顯著提高干細胞的治療效果。另外，為了解干細胞如何發(fā)揮治療效用、優(yōu)化治療方法等方面的信息，一些納米探針被用于標記示蹤干細胞注射或移植后在體內(nèi)的命運。從介紹干細胞治療入手，綜合分析了細胞治療目前存在的問題以及干細胞聯(lián)合生物材料治療的必要性，并對納米材料在干細胞示蹤成像方面的應(yīng)用以及納米材料負載化學(xué)藥物、基因藥物提高干細胞治療效果的研究現(xiàn)狀進行了綜述。隨著納米技術(shù)的發(fā)展以及人們對干細胞研究的深入，相信在不遠的將來，納米材料聯(lián)合干細胞將在疾病的治療中發(fā)揮越來越重要的作用。

Abstract:

Stem cell has made tremendous progress on the treatment of diseases due to its self-renewal and directed differentiation. However, its therapeutic effect needs to be further improved. Recently, bioactive nanoparticles consisting of nanoparticles or nanoparticles loaded with chemicals, cytokines, nucleotides and peptides, could significantly improve the therapeutic efficacy of stem cell. The bioactive nanoparticles could promote the survival, homing, differentiation and paracrine of stem cell and regulate its in vivo behaviors. In addition, in order to understand how stem cells play a therapeutic role and optimize treatment methods, the nanoprobes have been developed for tracking stem cell fate in vivo following administration or transplantation. Starting with the introduction of stem cells therapy, this paper comprehensively analyzed the current problems in cell therapy and the necessity of stem cells combined with biomaterial, and reviewed the applications of nanoparticles in stem cells tracing, as well as the research of nanoparticles loaded with chemical drugs and gene drugs to improve the therapeutic effect of stem cells. With the development of nanotechnology and the in-depth study of stem cells, it is believed that nanoparticles combined with stem cells will play an increasingly important role in the treatment of diseases in the near future.