文章信息/Info

Title:

Intelligent Hydrogels and Their Applications in Biological Fields

作者:

劉程; 喬麗媛; 柳承德; 楊力全; 蹇錫高

（大連理工大學化工學院 高分子材料系，遼寧 大連 116024）

Author(s):

LIU Cheng;  QIAO Liyuan;  LIU Chengde;  YANG Liquan;  JIAN Xigao

(Department of Polymer Materials, College of Chemical Engineering, Dalian University of Technology, Dalian 116024, China)

關鍵詞:

溫敏性; pH響應性; 自修復性; 藥物載體; 細胞負載與傳遞; 傷口敷料

Keywords:

temperature sensitivity;  pH responsiveness;  self�瞙ealing property;  drug delivery;  cell loading and delivery;  wound dressing

DOI:

10.7502/j.issn.1674-3962.201906001

文獻標志碼:

A

摘要:

水凝膠含水量極高、質地柔軟且具有優異的生物相容性。其中，智能水凝膠因其優異的環境響應性而備受關注。近年來，各類智能水凝膠層出不窮，其機械強度從數十帕變化到數十兆帕，在生物醫學領域的應用包括藥物載體、組織工程支架等。基于此，詳細總結了近年來智能水凝膠的發展及應用。首先，依據不同的分類方式對水凝膠進行了分類。進一步，重點對智能水凝膠進行了詳細的分類，包括溫敏性水凝膠、pH響應性水凝膠、自修復水凝膠等，同時對每類智能水凝膠的制備及應用進行了詳細的介紹。最后，概述了智能水凝膠在生物方向的應用，包括藥物載體、細胞負載與傳遞、傷口敷料等。

Abstract:

Hydrogels, with high water content, have soft texture and excellent biocompatibility. Among them, intelligent hydrogels have attracted much attention due to their excellent environmental responsiveness. The intelligent hydrogels emerge in endlessly in recent years, the mechanical strength of intelligent hydrogels changes from tens of Pa to tens of MPa, and they can be applied in biomedicine including drug carriers, tissue engineering scaffolds, etc. Based on this, this paper summarizes the development and applications of intelligent hydrogels in recent years. Firstly, hydrogels can be classified into different types according to different classification methods. Furthermore, this paper mainly summarizes different types of intelligent hydrogels, including temperature sensitive hydrogels, pH responsive hydrogels and self-healing hydrogels, also elaborates and analyzes the experimental cases of each kind of intelligent hydrogels in detail. Finally, the applications of various intelligent hydrogels in biological fields are summarized, including drug delivery, cell loading and delivery, wound dressing, etc.