文章信息/Info

Title:

Photocrosslinkable Silk Fibroin Hydrogels and Biomedical Application

文章編號:

1674-3962(2020)06-0421-09

作者:

李祥明; 王增凱; 董明東; 劉磊

（江蘇大學材料科學與工程學院新材料研究院，江蘇 鎮江 212013）

Author(s):

LI Xiangming; WANG Zengkai; DONG Mingdong; LIU Lei

（Institute for Advanced Materials，School of Materials Science and Engineering，Jiangsu University，Zhenjiang 212013，China）

關鍵詞:

絲素蛋白; 光交聯; 水凝膠; 生物材料; 生物醫學應用

Keywords:

silk fibroin; photocrosslinkable; hydrogel; biomaterial; biomedical application

分類號:

R318.08

DOI:

10.7502/j.issn.1674-3962.202003008

文獻標志碼:

A

摘要:

水凝膠是一類物理化學性質接近軟組織的先進材料，已有眾多聚合物用于水凝膠的制備。絲素蛋白由于具有優異的生物相容性、生物可降解性和易于制備成各種形式的材料等優點，在生物醫學領域中具有廣泛的應用，其中水凝膠是絲素蛋白在生物醫學中應用的重要形式。由于分子的獨特結構，絲素蛋白可以通過多種方法形成水凝膠。近年來，光交聯水凝膠由于具有制備條件溫和、副產物少、反應過程容易控制等優點，逐步成為研究的熱點。首先對絲素蛋白的分子結構和特性進行了介紹，總結了絲素蛋白水凝膠的制備方法，重點闡述了光交聯絲素蛋白水凝膠的研究現狀，并討論了它們在生物醫學領域的應用，最后對光交聯絲素蛋白水凝膠未來發展方向進行了展望。

Abstract:

Hydrogels are a kind of advanced materials with physical and chemical properties close to soft tissues. Many polymers have been used in the preparation of hydrogels. Silk fibroin has been widely used in biomedical application due to excellent biocompatibility, biodegradability and facility to fabricate into different types of materials. Hydrogel is an important form for silk fibroin in biomedical application and can be constructed by different approaches. Recently, the photocrosslinkable hydrogels have attracted enormous attention due to the impressive advantages such as mild preparation conditions, less by-product and excellent controllability. In this review, firstly, we present the molecular structure and characteristics of silk fibroin. Subsequently, the preparation methods of silk fibroin hydrogels are summarized. Furthermore, the preparation strategies of photocrosslinkable silk fibroin hydrogels are emphatically reviewed, and their applications in the biomedical field are discussed. Finally, the future research of the photocrosslinkable silk fibroin hydrogels is prospected.