文章信息/Info

Title:

Research Progress on Zeolitic Imidazolate Framework-8 for Biomacromolecules Delivery

文章編號:

1674-3962(2022)06-0458-08

作者:

李亞紅; 王劍; 羅鋒

（四川大學華西口腔醫院，四川 成都 610041）

Author(s):

LI Yahong;  WANG Jian;  LUO Feng

(West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

關鍵詞:

類沸石咪唑酯骨架-8（ZIF-8）; 藥物遞送; 生物大分子; 蛋白質; 酶; 核酸; 原位合成

Keywords:

zeolitic imidazolate framework-8 (ZIF-8);  drug delivery;  biomacromolecule;  protein;  enzyme;  nucleic acid;  in-situ synthesis

分類號:

R318.08

DOI:

10.7502/j.issn.1674-3962.202010006

文獻標志碼:

A

摘要:

類沸石咪唑酯骨架-8(zeolitic imidazolate framework-8, ZIF-8)是一種由Zn2+和2-甲基咪唑組成的新型金屬有機骨架材料,它具有孔隙率高、比表面積大、化學和熱穩定性好、表面性質可調及pH誘導生物降解性等優點，這些優點賦予了ZIF-8多種功能，使其能廣泛應用于氣體吸附與分離、催化、藥物傳遞等領域。近年來,研究人員通過原位合成的方法使ZIF-8可包封蛋白質、酶、核酸等生物大分子，生物大分子主要通過交聯、鍵合與ZIF-8骨架結合，并包埋在ZIF-8晶體內部或位于其表面。ZIF-8作為運載體可遞送蛋白質和酶以保持其生物學活性，提高其功能表現和穩定性；同時，ZIF-8亦可負載核酸藥物使其在胞內表達用于基因治療。綜述了這些方面的研究進展和應用，并對ZIF-8在相關生物醫學領域的應用進行了展望。

Abstract:

Zeolitic Imidazolate Framework-8 (ZIF-8), a novel metal-organic framework, is composed of zinc ions and 2-methylimidazole. It possesses advantages including high porosity, large specific surface area, good chemical and thermal stability, adjustable surface properties as well as pH-induced biodegradability. These advantages equip ZIF-8 with multiple functions, making it widely be used for gas adsorption and separation, catalysis, drug delivery and other fields. Recently, biomacromolecules such as proteins, enzymes and nucleic acids, can be encapsulated by ZIF-8 through in-situ synthesis to form composites. Biomacromolecules are embedded into ZIF-8 crystals or adhered to their surface through cross-linking and covalent bonding. ZIF-8 could serve as a carrier to deliver proteins and enzymes to maintain their biological activities, improving their functional performances and stability. Also, ZIF-8 could transmit nucleic acids, assisting them to express in cells for gene therapy. Therefore, this article reviews the recent research progress of ZIF-8 for biomacromolecules delivery on above issues, and prospects its application in related biomedical fields.