文章信息/Info

Title:

Recent Advances of Nano Metal-Organic Frameworks as Bio-Imaging Agents

文章編號(hào):

1674-3962(2022)10-0857-07

作者:

祁趙蕊1; 李旭蕊1; 韓莎莎1; 劉宇1; 2; 劉冰彌1; 2; 李麗1; 2

（1.遼寧大學(xué)藥學(xué)院，遼寧 沈陽 110036）（2.遼寧大學(xué)司法鑒定中心，遼寧 沈陽 110036）

Author(s):

QI Zhaorui1;  LI Xurui1;  HAN Shasha1;  LIU Yu1; 2;  LIU Bingmi1; 2;  LI Li1; 2

(1. School of Pharmacy, Liaoning University, Shenyang 110036, China) (2.Judicial Expertise Center, Liaoning University, Shenyang 110036, China)

關(guān)鍵詞:

金屬有機(jī)框架; 生物成像劑; 單模態(tài)成像; 雙模態(tài)成像; 多模態(tài)成像

Keywords:

metal-organic frameworks;  bio-imaging agents;  single-modal imaging;  dual-modal imaging;  tri-modal imaging

分類號(hào):

TB383

DOI:

10.7502/j.issn.1674-3962.202011029

文獻(xiàn)標(biāo)志碼:

A

摘要:

金屬有機(jī)框架材料(metal-organic frameworks, MOFs)由金屬離子和有機(jī)連接物通過配位化學(xué)組裝而成，具有不同于傳統(tǒng)無機(jī)材料的分子性質(zhì)、功能多樣性以及結(jié)構(gòu)和組成的可調(diào)性。與其他納米材料不同，作為一種新型的多孔晶體材料，納米尺度的MOFs(nano-MOFs, NMOFs)不僅保持了MOFs的結(jié)構(gòu)多樣性和物理化學(xué)特性，而且顆粒尺寸在幾十到數(shù)百納米范圍，使NMOFs在氣體吸附與分離、催化、磁性、傳感以及生物醫(yī)藥等不同領(lǐng)域表現(xiàn)出了優(yōu)異的性能。由于NMOFs具有比表面積大、孔隙率高、內(nèi)部孔道尺寸可調(diào)和表面可功能化等特性，其作為生物成像劑目前受到越來越多的關(guān)注。查閱了近15年來 NMOFs及其復(fù)合材料在成像方面應(yīng)用的文獻(xiàn)，總結(jié)了NMOFs作為生物成像劑，包括在單成像技術(shù)以及復(fù)合成像技術(shù)中的研究進(jìn)展，為后續(xù)研究人員提供參考。

Abstract:

Metal-organic frameworks (MOFs) are composed of metal ions and organic linkers through coordination chemistry. Their molecular properties, functional diversity and adjustable structure and composition are different from the traditional inorganic material. Different from other nanomaterials, as a new type of porous crystal materials, nano-MOFs(NMOFs) not only maintains the structural diversity and properties of MOFs both in physics and chemistry, but also shows particle sizes ranging from tens to hundreds of nanometers. These advantages make NMOFs exhibit excellent performance in gas adsorption and separation, catalysis, magnetism, sensing, biomedical application, etc. Because NMOFs have the characteristics of large specific surface area, high porosity, adjustable internal pore size and functionalized surface, they have attracted more and more attention as biological imaging agents. In this paper, we reviewed the literature of NMOFs and their composites for imaging in the past 15 years, and summarized the research progress of NMOFs as biological imaging agents, including single imaging technology and composite imaging technology, providing the basis for the subsequent researchers.