文章信息/Info

Title:

A State of Art of Hemodialysis Membranes in Hemocompatibility and Enhanced Removal of Toxins

文章編號:

1674-3962(2022)07-0520-05

作者:

葉卉; 侯笑洋; 黃莉蘭; 安珂; 李泓; 張玉忠

（天津工業大學材料科學與工程學院 省部共建分離膜與膜過程國家重點實驗室，天津 300387）

Author(s):

YE Hui;  HOU Xiaoyang;  HUANG Lilan;  AN Ke;  LI Hong;  ZHANG Yuzhong

(State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tiangong University, Tianjin 300387, China)

關鍵詞:

血液透析膜; 血液相容性; 尿毒癥毒素; 中分子毒素; 蛋白質結合化合物毒素

Keywords:

hemodialysis membrane;  hemocompatibility;  uremic toxins;  middle molecular toxin;  protein-binding compound toxin

分類號:

318.08

DOI:

10.7502/j.issn.1674-3962.202011030

文獻標志碼:

A

摘要:

慢性腎臟疾病患者體內內源性、外源性毒素的積累會加重腎臟負擔甚至導致尿毒癥，這些致病毒素被稱為尿毒癥毒素。血液透析是一種常見的終末期腎病治療手段，可以清除血液中游離的小分子尿毒癥毒素，但對中分子毒素和蛋白質結合化合物毒素的清除能力有限。血液透析膜材料的血液不相容往往會對患者健康造成影響，嚴重的會造成患者的病變甚至死亡。因此，改善血液透析膜的血液相容性和尿毒癥毒素的強化清除成為了該領域的研究熱點。傳統改性方法中，通過膜表面親水改性和表面帶負電可以改善其血液相容性，在擴散基礎上引入對流或吸附機制可以強化尿毒癥毒素的清除。除傳統改性方法外，一些新型血液透析膜也被開發用于改善血液透析膜的血液相容性以及尿毒癥毒素的強化清除，如蛋白質仿生膜、納米通道定向傳輸膜、三維模板多層纖維膜、抗凝生物膜以及自抗凝膜。介紹了血液透析膜在血液相容性和毒素強化清除方面的研究進展，為血液透析膜改性工作提供參考。

Abstract:

Accumulation of endogenous and exogenous toxins in patients with chronic kidney disease will increase the burden on the kidneys and even lead to uremia. These substances are called uremic toxins. Hemodialysis is a common treatment for end-stage renal disease. This treatment can remove free small molecule uremic toxins in the blood, but it is limited to remove middle molecular toxins and protein-binding compound toxins. Moreover, the blood incompatibility of hemodialysis membrane materials often affects the health of patients, and even cause disease or even death. Therefore, improving the hemocompatibility of hemodialysis membranes and strengthening their elimination performance have become hotspots in this field. In traditional modification methods, the hemocompatibility of hemodialysis membranes can be improved by hydrophilic modification and negative charge on the membrane surface, and the removal of uremia toxin can be enhanced by adding convection or adsorption mechanism on the basis of diffusion. Moreover, several novel hemodialysis membranes have also been developed to improve the biocompatibility and enhance removal of uremic toxins, such as protein bionic membranes, nanochannel directional transport membranes, 3D template multilayer fiber membranes, anticoagulant membranes and self�瞐nticoagulation membranes. This article introduces the research progress of hemodialysis membranes in terms of hemocompatibility and enhanced removal of toxins, which provides references for the modification of hemodialysis membranes.