文章信息/Info

Title:

Research and Application Progress of Hemoglobin Oxygen Carrier

文章編號:

1674-3962(2022)05-0338-07

作者:

李菂1; 韓樾夏2; 楊芳1

（1. 東南大學(xué)生物科學(xué)與醫(yī)學(xué)工程學(xué)院 江蘇省生物材料與器件重點(diǎn)實(shí)驗(yàn)室，江蘇 南京 210096）（2. 中國科學(xué)院空間應(yīng)用工程與技術(shù)中心，北京 100094）

Author(s):

LI Di1;  HAN Yuexia2;  YANG Fang1

(1. Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China) (2. Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing 100094, China)

關(guān)鍵詞:

血紅蛋白; 氧載體; 氧氣傳輸系統(tǒng); 乏氧; 修飾; 包載

Keywords:

hemoglobin;  oxygen carrier;  oxygen delivery system;  hypoxia;  modification;  encapsulation

分類號:

R457; R963; TQ460.6

DOI:

10.7502/j.issn.1674-3962.202104022

文獻(xiàn)標(biāo)志碼:

A

摘要:

人體多種疾病的發(fā)生常伴隨著缺氧情況和乏氧微環(huán)境的出現(xiàn)，因此，研發(fā)性能良好的氧載體，在疾病病灶特異性遞送高濃度的氧氣，有望成為相關(guān)疾病治療的新方法之一。血紅蛋白來源于生物體本身，是紅細(xì)胞的主要組成部分，其依靠分子中心血紅素中的鐵原子承擔(dān)機(jī)體氧氣運(yùn)輸?shù)墓δ堋Ｒ蚱洫?dú)特的攜氧特性以及優(yōu)異的生物相容性與安全性，成為人工攜載氧的優(yōu)良仿生生物載體。然而，由于游離血紅蛋白具有運(yùn)載缺陷與腎毒性，研究者們通過偶聯(lián)、交聯(lián)、吸附等化學(xué)修飾或脂質(zhì)體、聚合物等微囊包封等多種手段，在實(shí)現(xiàn)高氧負(fù)載的條件下，增長其循環(huán)時(shí)間。構(gòu)建的這些新型氧載體結(jié)構(gòu)被用于貧血、腦損傷、惡性腫瘤、缺血性休克、骨骼肌疲勞及器官肢體灌注的治療。綜述了近年來血紅蛋白氧載體材料加工制備中的相關(guān)化學(xué)修飾與微囊封裝手段與方法，及其面向多類疾病的治療應(yīng)用與結(jié)合其它療法的聯(lián)合治療應(yīng)用。

Abstract:

The occurrence of a variety of human diseases is often accompanied by the emergence of hypoxia and hypoxic microenvironment. Therefore, the development of oxygen carriers with good performance becomes the key to overcome various diseases and achieve many medical functions. Hemoglobin comes from the live organism. As the main component of red blood cells, hemoglobin relies on the iron atom in the molecular center heme to play the function of oxygen transport. Because of its unique oxygen carrying properties, excellent biocompatibility as well as safety, hemoglobin has become a good choice for artificial oxygen carrier. Due to the transport defects and nephrotoxicity of free hemoglobin, researchers have extended its circulation time, improved its oxygen carrying efficiency, expanded its applicable conditions and enriched its medical functions by chemical modification such as coupling, cross-linking and adsorption or microencapsulation with liposome and polymer. These oxygen carriers are used to treat anemia, brain injury, malignant tumor, ischemic shock, skeletal muscle fatigue and organ and limb perfusion. This paper reviews the chemical modification and microencapsulation methods in the preparation of hemoglobin oxygen carriers in recent years, as well as the treatment methods for many kinds of diseases and the combined application with other therapies.