文章信息/Info

Title:

Research Progress of Molecularly Imprinted Fluorescence Detection System with Carbon Quantum Dots

文章編號:

1674-3962(2023)03-0228-10

作者:

孫文瑾1; 2; 3; 李瑞珍1; 2; 3; 劉偉峰1; 2; 3; 劉旭光1; 2; 3

(1. 太原理工大學 新型碳材料研究院，山西 太原 030024) (2. 太原理工大學材料科學與工程學院，山西 太原 030024) (3. 新材料界面科學與工程教育部重點實驗室，山西 太原 030024)

Author(s):

SUN Wenjin1; 2; 3; LI Ruizhen1; 2; 3; LIU Weifeng1; 2; 3; LIU Xuguang1; 2; 3

(1. Institute of New Carbon Materials, Taiyuan University of Technology, Taiyuan 030024, China) (2. School of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China) (3. Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan 030024, China)

關鍵詞:

碳量子點; 分子印跡; 熒光檢測; 構建策略; 工作機理

Keywords:

carbon quantum dots;  molecular imprinting;  fluorescence detection;  construction strategy;  working mechanism

分類號:

TB34;O657.3;TP212

DOI:

10.7502/j.issn.1674-3962.202106003

文獻標志碼:

A

摘要:

復雜基質中痕量分析物的高選擇性和高靈敏度檢測對環境保護和食品安全等問題具有重要意義。近年來，色譜法等傳統檢測方法可達到高靈敏度檢測的需求，但在選擇性、樣品預處理過程、維護費用等方面不同程度地存在欠缺，因此迫切需要尋求一種兼具高靈敏度和高選擇性，且成本低廉、簡便快速的檢測手段。將碳量子點（carbon quantum dots, CQDs）的熒光檢測與分子印跡材料（molecularly imprinted polymers, MIPs）的分子識別耦合起來，構建高效的碳量子點分子印跡（CQDs-MIPs）熒光檢測體系，合成路線簡單、成本低廉，對目標物質的檢測具有高靈敏度、高選擇性和強的抗干擾能力，將會在復雜基質中極低濃度物質的檢測方面發揮重要作用。MIPs具有與目標分子高度匹配的識別位點，可實現對目標分子的選擇性識別和富集；CQDs作為一種新型的碳基納米熒光材料，具有優異的光學特性、良好的水溶性和生物相容性，且綠色環保、無毒無害，對目標分子的高靈敏熒光響應使它在熒光檢測領域具備不可替代的優勢。綜述了CQDs-MIPs檢測體系的構建策略和工作機理，以及近年來在環境、食品和臨床領域的應用進展，同時對其未來的發展方向進行了合理的預測。

Abstract:

The highly selective and sensitive detection of trace analytes in complicated matrix is of great significance to environmental protection and food safety. So far, traditional detection methods such as chromatography can realize high sensitivity detection. However, the detection processes suffer from some defects to some extent in selectivity, sample pretreatment process, and maintenance cost. Therefore, it is urgent to establish a simple and rapid detection method with high selectivity and high sensitivity. By coupling carbon quantum dots (CQDs) for fluorescence detection with molecularly imprinted polymers (MIPs) for molecular recognition, an efficient CQDs-based molecularly imprinted (CQDs-MIPs) fluorescence detection system is constructed. The system has facile synthesis route, low cost, high sensitivity, high selectivity, and strong anti-interference ability, and thus plays an important role in the detection of extremely low concentration analytes in complex matrix. MIPs can selectively recognize and enrich the target molecules owing to the recognition sites highly matching the target molecules. As one class of the new carbon�瞓ased fluorescent nanomaterials, CQDs are environment-friendly, non-toxic, harmless, and have excellent optical properties, good water solubility and biocompatibility, exhibiting irreplaceable advantages in the field of molecular detection based on their fluorescence response. This review mainly focuses on the construction strategies and sensing mechanism of CQDs-MIPs detection systems, and their application progresses in environmental, food and clinical fields in recent years. In addition, the future development of CQDs-MIPs is forecasted.