文章信息/Info

Title:

Research Progress of Lipiodol Emulsion in Transarterial Interventional Embolization for Hepatocellular Carcinoma

文章編號:

1674-3962(2022)09-0742-07

作者:

張洪瑞1; 陳虎1; 朱靖1; 毛景松2; 劉剛1

（1．廈門大學公共衛生學院 分子影像暨轉化醫學研究中心，福建 廈門 361102）（2．廈門大學附屬翔安醫院 介入科，福建 廈門 361102）

Author(s):

ZHANG Hongrui1;  CHEN Hu1;  ZHU Jing1;  MAO Jingsong2;  LIU Gang1

(1. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China) (2. Department of Intervention, Xiang’an Hospital, Xiamen University, Xiamen 361102, China)

關鍵詞:

碘油乳劑; 穩定性; 肝細胞癌; 介入治療

Keywords:

lipiodol emulsion;  stability;  hepatocellular carcinoma;  interventional therapy

分類號:

R815

DOI:

10.7502/j.issn.1674-3962.202109037

文獻標志碼:

A

摘要:

碘油因其特異性滯留于肝細胞癌組織的性質已成為肝細胞癌（hepatocellular carcinoma, HCC）患者介入治療最常用的栓塞劑。以碘油為載體，混合各類抗腫瘤藥物制備成的新型碘油藥物乳劑用于中晚期肝癌介入栓塞治療的策略已得到臨床廣泛研究應用。但是不同碘油藥物乳劑的適應癥和療效存在較大差異，并且目前碘油乳劑普遍存在著穩定性能不佳的難題，限制了碘油乳劑在HCC介入治療中的發展和應用。科學選用碘油藥物乳劑及增加碘油乳劑的穩定性將是提高中晚期肝癌介入栓塞治療療效的關鍵。對碘油聯合藥物的種類以及增加碘油乳劑穩定性的相關方法進行綜述，為臨床實踐提供參考。

Abstract:

Transarterial interventional embolization is one of the commonly used methods that are not suitable for surgical resection of patients with hepatocellular carcinoma. Lipiodol has become the most commonly used embolization agent for interventional therapy of hepatocellular carcinoma (HCC) due to its specific retention in HCC tissues. Using lipiodol as a carrier and mixing various anti�瞭umor drugs to prepare lipiodol drug emulsions for interventional embolization of advanced HCC strategies has been widely studied and applied in clinical practice. However, the application scenarios and curative effects of different lipiodol drug emulsions are quite different, and the current lipiodol emulsion generally has the problem of poor stability, which limits the development and application of lipiodol emulsion in interventional treatment of HCC. The scientific selection of lipiodol emulsion and increasing the stability of lipiodol emulsion will be the key to improve the curative effect of interventional embolization of advanced HCC.This article will review the types of lipiodol combined drugs and the related methods to increase the stability of lipiodol emulsion, so as to provide reference for clinical practice.