文章信息/Info

Title:

Photodynamic Antibacterial Therapy Based on Polymer Materials

文章編號:

1674-3962(2022)07-0508-12

作者:

孫玉潔; 高敏政; 朱藝文; 鄭良; 俞丙然; 徐福建

（北京化工大學材料科學與工程學院，北京 100029）

Author(s):

SUN Yujie; GAO Minzheng; ZHU Yiwen; ZHENG Liang; YU Bingran; XU Fujian

(College of Materials Science and Engineering, Beijing University of Chemical and Technology, Beijing 100029, China)

關鍵詞:

聚合物材料; 光動力抗菌治療; 廣譜性; 細菌靶向; 微環境響應

Keywords:

polymer materials;  photodynamic antibacterial therapy;  broad-spectrum;  bacteria-targeting;  microenvironmental response

分類號:

TB381

DOI:

10.7502/j.issn.1674-3962.202112015

文獻標志碼:

A

摘要:

細菌感染是目前人類面臨的最為嚴重的健康問題之一，常規抗生素治療面臨著細菌耐藥性等問題，光動力抗菌療法因具有抗菌譜廣、非侵入性以及不易引發耐藥性的特點而廣受關注，但傳統小分子光敏劑由于水溶性較差、缺乏組織靶向性以及對正常組織細胞存在光照毒性等缺點而限制了后續的生物應用。首先介紹了光動力抗菌治療的基本原理，然后概述了廣譜性光動力抗菌高分子材料、細菌靶向性光動力高分子材料、微環境響應性光動力高分子材料這幾種光動力材料的研究進展，并對每種光動力治療材料的構建進行了簡要分析，最后總結了目前構建新型聚合物基光動力抗菌材料所面臨的主要問題，提出了未來構建新型光動力抗菌材料的發展方向，希望為我國光動力抗菌治療的發展提供參考。

Abstract:

Bacterial infesctions are currently one of the most serious health problems facing humans. Conventional antibiotic treatments are faced with problems such as bacterial resistance. Photodynamic antibacterial therapy is widely used because of its broad antibacterial spectrum, non-invasiveness, and uneasy to cause drug resistance. However, traditional small molecule photosensitizers have limited clinical applications due to their poor water solubility, lack of tissue targeting, and phototoxicity to normal tissue cells. This article first introduced the basic principles of photodynamic antibacterial therapy, then summarized the research progress of broad-spectrum photodynamic therapy, bacterial-targeted photodynamic therapy, and microenvironment-responsive photodynamic therapy, and briefly analyzed the construction of each photodynamic therapy material, then summarized the main problems facing the current construction of new polymer-based photodynamic antibacterial materials, and proposed direction of building new photodynamic antibacterial materials in the future. This article provides an important reference to the development of photodynamic antibacterial therapy in China.