文章信息/Info

Title:

Research Progress of the Iron-Based Magnetic Nanomaterials for Neuromodulation

文章編號:

1674-3962(2022)09-0669-09

作者:

柳東芳1; 顧寧2

(1.東南大學醫學院 江蘇省分子影像與功能影像實驗室，江蘇 南京 210009） (2.東南大學生物科學與醫學工程學院 生物電子學國家重點實驗室 江蘇省生物材料與器件重點實驗室，江蘇 南京 210009）

Author(s):

LIU Dongfang1;  GU Ning2

(1.Jiangsu Key Laboratory of Molecular and Functional Imaging, School of Medicine, Southeast University, Nanjing 210009, China) (2.Jiangsu Key Laboratory of Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, China)

關鍵詞:

磁性納米材料; 神經調控; 磁場調控; 氧化鐵納米顆粒; 磁遺傳學; 磁熱遺傳學

Keywords:

magnetic nanomaterials;  regulation of neurons;  magnetic regulation;  iron oxide nanoparticles (NPs); magnetogenetics; magnetothermal genetics

分類號:

TB34; R318.08

DOI:

10.7502/j.issn.1674-3962.202112028

文獻標志碼:

A

摘要:

鐵基磁性納米材料能夠將外部磁場轉化為局部的熱、電、機械力等刺激信號，實現對神經元的遠程無線精準調控，在研究神經網絡功能和神經疾病治療領域都具有良好的應用前景。從基于磁性納米顆粒的磁遺傳學、磁熱遺傳學、磁電效應、磁致機械力和磁化學遺傳學神經調控5個方面綜述磁性納米材料介導的神經調控技術，討論磁性納米材料在腦內的植入穩定性、生物安全性及與細胞膜的相互作用，并對用于神經調控的鐵基磁性納米材料的未來發展進行展望。

Abstract:

Iron-based magnetic nanomaterials can transform magnetic field into local energy such as thermal, electrical and mechanical stimulation. With the assistance of the magnetic nanoparticles, precise remote wireless regulation of neurons can be realized by applying external magnetic field, which provides a good application prospect in both of the basic research of neuroscience and the clinical treatment of nerve diseases. This paper reviewed the application of the magnetic nanoparticles in magnetogenetics, magnetothermal genetics, magnetoelectric effect, magnetic field induced mechanical force and chemomagnetic neural regulations. The stable duration and in vivo biosafety of the implanted nanomaterials，as well as the interaction between the nanomaterilas and cell membrane were discussed. At last, the future development of the iron-based magnetic nanomaterials in neural regulation was prospected.