[1]姜琴,耿鵬,張雯,等.聲敏劑在腫瘤聲動力治療中的研究進展[J].中國材料進展,2022,41(09):730-741.[doi:10.7502/j.issn.1674-3962.202205002]
JIANG Qin,GENG Peng,ZHANG Wen,et al.Research Progress of Sonosensitizers in Tumor Sonodynamic Therapy[J].MATERIALS CHINA,2022,41(09):730-741.[doi:10.7502/j.issn.1674-3962.202205002]
點擊復制
聲敏劑在腫瘤聲動力治療中的研究進展(
)
中國材料進展[ISSN:1674-3962/CN:61-1473/TG]
- 卷:
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41
- 期數:
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2022年第09期
- 頁碼:
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730-741
- 欄目:
-
- 出版日期:
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2022-09-30
文章信息/Info
- Title:
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Research Progress of Sonosensitizers in Tumor Sonodynamic Therapy
- 文章編號:
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1674-3962(2022)09-0730-12
- 作者:
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姜琴; 耿鵬; 張雯; 陳志鋼
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（東華大學材料科學與工程學院 纖維材料改性國家重點實驗室，上海 201620）
- Author(s):
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JIANG Qin; GENG Peng; ZHANG Wen; CHEN Zhigang
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(State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China)
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- 關鍵詞:
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聲敏劑; 納米材料; 有機無機雜化; 聲動力治療; 腫瘤
- Keywords:
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sonosensitizer; nanomaterials; organicinorganic hybrid; sonodynamic therapy; tumor
- 分類號:
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TB34; R318.08; R730.5
- DOI:
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10.7502/j.issn.1674-3962.202205002
- 文獻標志碼:
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A
- 摘要:
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發展腫瘤治療新方法對提高癌癥病人的生存率具有重要意義。聲動力治療（sonodynamic therapy, SDT）是近年來快速發展的一種腫瘤治療新方法，具有非侵入性、高時空分辨性和低毒副作用等優點。SDT是利用超聲波激發腫瘤部位的聲敏劑，使其吸收能量并與腫瘤中的氧氣作用產生毒性活性氧，誘導腫瘤細胞凋亡或壞死，其核心是開發安全且高效的聲敏劑。討論了SDT作用的可能機理，重點介紹了近年來可用于SDT的聲敏劑的研究進展，包括有機分子、無機納米和有機無機雜化納米聲敏劑，并對其腫瘤治療效果進行了評價。最后，指出了當前SDT存在的挑戰和未來走向臨床應用的發展方向。
- Abstract:
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Developing new methods that can effectively cure tumors is of significance to improve the survival rate of cancer patients. Sonodynamic therapy (SDT) is a new tumor treatment method developed rapidly in recent years, and it exhibits some advantages such as non-invasiveness, high temporal and spatial resolution and low side effects. SDT uses ultrasound to stimulate sonosensitizers accumulated at the tumor site, and then the sonosensitizers absorb ultrasound energy and interact with oxygen in the tumor to generate reactive oxygen species (ROS) which further induce tumor cells apoptosis or necrosis. The key of SDT is to develop safe and efficient sonosensitizers. This review firstly discusses the possible mechanism of SDT. Then, the research progress of sonosensitizers that have been used in SDT in recent years is introduced, including organic molecule sonosensitizers, inorganic nano sonosensitizers, and organic-inorganic hybrid nano sonosensitizers, and their tumor therapeutic efficacies are also evaluated. Finally, the existing challenges of SDT and the development direction of SDT for future clinic application are discussed.
備注/Memo
- 備注/Memo:
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收稿日期：2022-05-02 修回日期：2022-07-28 基金項目：國家自然科學基金資助項目(51972056)；上海市曙光技術項目(18SG29)；優秀學術帶頭人計劃項目(20XD1420200)；中央高校基本科研業務費專項資助項目(2232022D-02) 第一作者：姜琴，女，1988年生，講師通訊作者：陳志鋼，男，1979年生，教授，博士生導師， Email: zgchen@dhu.edu.cn
更新日期/Last Update:
2022-08-22