文章信息/Info

Title:

Research Progress of Layered Double Hydroxides in Tumor Diagnosis and Therapy

文章編號:

1674-3962(2022)09-0718-12

作者:

李高明1; 郭云琦1; 鞏軍麗1; 張貴祥2; 史向陽1; 沈明武1

（1. 東華大學生物與醫學工程學院，上海 201620）（2. 同濟大學附屬上海市第四人民醫院 放射影像科，上海 200434）

Author(s):

LI Gaoming1;  GUO Yunqi1;  GONG Junli1;  ZHANG Guixiang2;  SHI Xiangyang1;  SHEN Mingwu1

(1. College of Biological Science and Medical Engineering,Donghua University, Shanghai 201620, China) (2. Department of Radiology, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai 200434, China)

關鍵詞:

納米醫學; 精準治療; 納米材料; 層狀雙金屬氫氧化物; 腫瘤; 診斷; 治療

Keywords:

nanomedicine;  precision therapy;  nanomaterials;  layered double hydroxides;  tumors;  diagnosis;  therapy

分類號:

TB383；R318.08

DOI:

10.7502/j.issn.1674-3962.202207026

文獻標志碼:

A

摘要:

納米醫學的發展拓展了生物醫學的研究范疇，尤其是在腫瘤的精準診療領域擔當了重要角色。在各種納米材料中，層狀雙金屬氫氧化物（layered double hydroxides，LDH）是一種典型的二維納米材料，具有良好的生物相容性和膠體穩定性、較大的荷載量、易功能化修飾等優點，在腫瘤的診療領域受到研究者們的廣泛關注。近年來，越來越多結構精巧、性能優良、副作用小的LDH基納米平臺在這一領域被報道。介紹了LDH納米顆粒的結構與性質，總結了LDH基納米平臺的構建策略，概述了近5年LDH基納米平臺在腫瘤診療領域的最新進展，最后還討論了LDH基納米平臺向臨床醫學及精準治療應用的挑戰和未來發展策略，希望能夠引起研究者對LDH基納米平臺在腫瘤診療領域更廣泛的研究興趣。

Abstract:

The development of nanomedicine has expanded the research boundary of biomedicine, especially in the field of precision tumor diagnosis and therapy. Among various nanomaterials, layered double hydroxides (LDH), a typical two-dimensional nanomaterial with good biocompatibility and colloidal stability, large loading capacity, easy functional modification, has attracted extensive attention of researchers in the field of tumor theranostics. In recent years, more and more LDH-based nanoplatforms with exquisite structure, excellent performance and low side effects have been reported in this field. This review introduces the structure and properties of LDH nanoparticles, summarizes the construction strategies of LDH-based nanoplatforms, and summarizes the latest progress of LDH-based nanoplatforms in tumor diagnosis and treatment in the past five years. The challenges and future development strategies for LDH-based nanomedicines toward clinical medicine and precision therapy applications are also discussed. It is hoped that this review will arouse researchers’ wide interest in LDH-based nanoplatforms in the field of tumor theranostics.