文章信息/Info

Title:

Research Progress of MOFs-Derived Nanozymes in Tumor Therapy

文章編號:

1674-3962(2022)09-0706-12

作者:

覃麗婷; 孫蕓; 徐柏龍; 劉惠玉

（北京化工大學 有機無機復合材料國家重點實驗室，北京 100029）

Author(s):

QIN Liting; SUN Yun; XU Bolong; LIU Huiyu

（Key Laboratory of Organic�睮norganic Composites, Beijing University of Chemical Technology, Beijing 100029, China）

關鍵詞:

金屬有機框架; 納米酶; 活性調控; 催化療法; 腫瘤治療

Keywords:

metal organic framework;  nanozyme;  activity regulation;  catalytic therapy;  tumor therapy

分類號:

TB383.1;R318.08; R730.4

DOI:

10.7502/j.issn.1674-3962.202208005

文獻標志碼:

A

摘要:

納米酶是具有類酶活性的納米材料，與天然酶相比，納米酶具有易于合成、活性可調和高穩定性的優勢。金屬有機框架（metal-organic frameworks，MOFs）衍生納米酶作為納米酶家族的新成員，因其豐富的活性位點和可控的催化活性，吸引了研究者的廣泛關注。與傳統納米酶相比，MOFs衍生納米酶保留了MOFs的多孔結構，同時表現出良好的生物相容性和高催化活性，在包括腫瘤催化治療在內的生物醫學應用中展現出廣闊的前景。系統地總結了MOFs衍生納米酶的種類，包括MOFs衍生的金屬氧化物、金屬/碳、金屬氧化物/碳、金屬硫化物以及單原子納米酶。此外，重點討論了MOFs衍生納米酶的活性調控策略，如表面結構調控、雜原子摻雜、雙金屬構建和基于MOFs的配體交換策略。同時，回顧了近年來MOFs衍生納米酶介導的催化治療及其聯合其他療法在抗腫瘤領域的應用。最后，總結了MOFs衍生納米酶目前在生物醫學領域中面臨的挑戰和前景，以期推動MOFs衍生納米酶的開發并拓展其進一步的生物醫學應用轉化。

Abstract:

Nanozymes are a class of nanomaterials with enzyme-like activity. Compared with natural enzymes, nanozymes have the advantages of easy synthesis, adjustable activity, and high stability. The nanozymes derived from the metal-organic frameworks (MOFs), as a new family member of nanozymes, have attracted widespread attention due to their rich active sites and controllable catalytic activity. Compared with the traditional nanozymes, MOFs-derived nanozymes maintain the porous structure of MOFs, as well as possess good biocompatibility and high catalytic activity, showing a broad prospect in the biomedical field including tumor catalytic therapy. In this review, we systematically summarize the classification of MOFs-derived nanozymes, including MOFs-derived metal oxides, metal/carbon, metal oxides/carbon, metal sulfide, and single-atom nanozymes (SAzymes). In addition, we also focus on the activity regulation strategies of MOFs-derived nanozymes, such as surface structure regulation, heteroatomic doping, bimetallic construction, and MOFs-based linker exchange strategy. Furthermore, we review the applications of catalytic therapies based on MOFs-derived nanozymes and their synergistic therapies in recent years. Finally, we propose the challenges and prospects of MOFs-derived nanozymes in the biomedical field, to promote the development of MOFs-derived nanozymes and expand their further biomedical application transformation.