文章信息/Info

Title:

Research Progress of Drug Delivery Systems Based on Living Cells and Their Derivatives

文章編號:

1674-3962(2022)09-0697-09

作者:

張蒙; 黃容琴

（復旦大學藥學院，上海 201203）

Author(s):

ZHANG Meng; HUANG Rongqin

(School of Pharmacy, Fudan University, Shanghai 201203, China)

關鍵詞:

活細胞及其衍生物; 藥物載體; 藥物釋放; 靶向遞送; 腫瘤治療

Keywords:

living cells and their derivatives;  drug carrier;  drug release;  targeted delivery;  tumor therapy

分類號:

R730.59

DOI:

10.7502/j.issn.1674-3962.202208008

文獻標志碼:

A

摘要:

目前，對病變組織或細胞的靶向性不足是藥物遞送研究領域存在的一個重大挑戰。大量研究表明，基于納米顆粒的靶向藥物遞送系統已經給癌癥治療帶來新希望，但仍存在生物相容性差、不可控降解、細胞毒性高和具有免疫原性等問題。相比之下，活細胞及其衍生物通常具有固有的靶向能力、高載藥能力和生物屏障穿透能力，可作為藥物載體控制藥物釋放，從而提高藥物在病灶組織或細胞的累積和治療效率。首先綜述了免疫細胞、無核細胞、干細胞、細菌等活細胞及其衍生物作為藥物遞送載體的主要研究進展；同時，對不同載藥系統的靶向遞送機制及優缺點進行了闡述；最后，對活細胞及其衍生物作為遞藥載體的臨床轉化潛力進行了展望。

Abstract:

Currently, one of the significant challenges remaining in the field of drug delivery research is insufficient targeting to diseased tissues or cells. The massive research indicated that, targeted drug delivery systems based on nanoparticles have shown a new hope in cancer treatment, but there still exist some problems including poor biocompatibility, uncontrollable degradation, high cytotoxicity and immunogenicity. In contrast, living cells usually have innate targeting ability, high drug loading capability and biological barrier penetration ability, and can be used as drug delivery vehicles to control drug release, so as to improve the accumulation and treatment efficiency of drugs on the focal tissues or cells. This review dwelled on the researches of immune cells, anucleated cells, stem cells, bacteria and their derivatives as drug delivery carriers. Meanwhile, the mechanism, advantages and disadvantages of different drug delivery systems were also discussed. Finally, the potential for clinical transformation and the prospect of live cells and their derivatives as drug delivery carriers were proposed.