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細胞粘附的兩性離子功能化聚對二甲苯薄膜()

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中國材料進展[ISSN:1674-3962/CN:61-1473/TG]

卷:: 42
期數(shù):: 2023年第07期

頁碼:: 559-565

欄目:

出版日期:: 2023-07-31

文章信息/Info

Title:: Zwitterions Functionalized Parylene for Protein/Cell Repulsion

文章編號:: 1674-3962(2023)07-0559-07

作者:: 錢思昊1; 2; 潘齊超1; 2; 張亞瓊1; 2; 何勇1; 朱波2; 1.東華大學材料科學與工程學院纖維材料改性國家重點實驗室，上海 201620 2.上海大學材料科學與工程學院，上海 200444

Author(s):: QIAN Sihao1; 2; PAN Qichao1; 2; ZHANG Yaqiong1; 2; HE Yong1; ZHU Bo2; 1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China 2. School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China

關鍵詞:: 聚對二甲苯; 兩性離子; 磷酸膽堿; 抗非特異性粘附; 圖案化

Keywords:: parylene; zwitterion; phosphorylcholine; antifouling; pattern

分類號:: O632.7+1

DOI:: 10.7502/j.issn.1674-3962.202210017

文獻標志碼:: A

摘要:: 目前生物電子器件材料在復雜的生物環(huán)境中容易粘附蛋白/細胞等，進而影響器件的長期穩(wěn)定性。研究并制備了抗非特異性蛋白/細胞粘附的兩性離子功能化聚對二甲苯薄膜材料。通過原子轉(zhuǎn)移自由基聚合方法在具有溴引發(fā)劑的聚對二甲苯表面接枝兩性離子基團得到該薄膜材料。探索了不同兩性離子聚合物分子鏈——聚甲基丙烯酸甲酯磷酸膽堿（PMPC）、聚甲基丙烯酸甲酯磺酸甜菜堿（PMSB）、聚甲基丙烯酸甲酯羧酸甜菜堿（PMCB）修飾的聚對二甲苯抗蛋白和細胞粘附的能力，發(fā)現(xiàn)PMPC修飾的聚對二甲苯性能最為優(yōu)異。此外，采用光刻技術制備了PMPC修飾的聚對二甲苯圖案化的生物界面，實現(xiàn)了在空間上控制細胞粘附行為。為聚對二甲苯薄膜的表面抗炎癥細胞粘附及控制神經(jīng)細胞生長提供了可能性，在生物電子器件領域具有潛在的應用價值。

Abstract:: Biomaterials for bioelectronics are susceptible to the adhesion of proteins/cells, which will affect the chronic stability of devices. Here, Anti-fouling parylene films were studied and prepared to resist the adhesion of proteins or cells. Bromine functionalized parylene film was first deposited on parylene, and then, atom transfer radical polymerization was conducted to modify parylene with zwitterions. Three different types of zwitterionic polymers, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), poly(2-methacryloyloxyethyl sulfobetaine) (PMSB) and poly(2-methacryloyloxyethyl carboxybetaine) (PMCB) were used to modify parylene, and their properties were studied. It was observed that PMPC-functionalized parylene showed the best antifouling properties. Moreover, the PMPC-functionalized parylene was also utilized to fabricate patterned bio-platform by a lithography-combined microfabrication for spatially guiding neural cell attachment. These zwitterionic functionalized parylene films, which can resist anti-inflammatory cells and control the growth of nerve cells, have a promising future in the field of bioelectronic devices.

參考文獻/References:

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備注/Memo

備注/Memo:: 收稿日期：2022-10-14修回日期：2023-02-17 基金項目：國家自然科學基金資助項目（22175111，21474014）第一作者：錢思昊，女，1991年生，博士研究生通訊作者：朱波，男，1971年生，教授，博士生導師， Email:bozhu@shu.edu.cn

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