文章信息/Info

Title:

Recent Advance on New Indocyanine Green IR-820 in Near-Infrared Fluorescence Imaging and Photothermal and Synergetic Therapy of Tumor

文章編號:

1674-3962(2024)08-0734-09

作者:

朱麗君; 樊慧敏; 李慧; 杜仲; 王蕾; 張學良; 尼沙·阿力甫

1. 新疆醫科大學第二附屬醫院，新疆 烏魯木齊 830054 2. 新疆醫科大學醫學工程技術學院，新疆 烏魯木齊 830054 3. 新疆醫科大學公共衛生學院，新疆 烏魯木齊 830054 el at

Author(s):

ZHU Lijun;  FAN Huimin;  LI Hui;  DU Zhong;  WANG Lei; ZHANG Xueliang;  NUERNISHA Alifu

1.The Second School of Clinical Medicine of Xinjiang Medical University, Urumqi 830054, China 2.School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, China 3. Institute of Public Health, Xinjiang Medical University, Urumqi 830054, China et al.

關鍵詞:

有機熒光染料; 新吲哚菁綠IR��820; 近紅外熒光成像; 光熱治療; 協同治療; 腫瘤

Keywords:

organic fluorescent dye;  new indocyanine green IR-820;  near-infrared fluorescence (NIRF) imaging;  photothermal therapy;  synergistic therapy;  tumor

分類號:

TQ617.3;R318.08

DOI:

10.7502/j.issn.1674-3962.202211005

文獻標志碼:

A

摘要:

新吲哚菁綠IR-820因其具有強近紅外(near�瞚nfrared, NIR, 750~1700 nm)熒光特性、良好生物相容性、高光熱轉換效率及穩定性等優勢，在NIR發光的有機熒光染料中脫穎而出，被廣泛應用于生物醫學成像、熒光標記、細胞實時監測、光熱治療等研究領域。為更好地發揮IR��820的生物醫學應用價值，研究人員用不同生物化學分子修飾IR-820來增強其熒光及光熱特性，制備多種類的熒光納米粒子，在基礎生物醫學成像與腫瘤光熱治療方面開展了眾多研究。總結了IR-820熒光納米粒子在近紅外熒光成像和通過光熱機理及與其他技術協同治療腫瘤中的應用研究，希望為進一步推進有機熒光染料IR-820在生物醫學領域應用和臨床轉化發展提供參考。

Abstract:

With the advantages of strong near-infrared (NIR, 760~1700 nm) fluorescence emission, good biocompatibility, high photothermal conversion efficiency and good stability, the new indocyanine green IR-820 has stood out among the existing organic NIR fluorescent dyes and has been widely used in the research fields of biomedical imaging, fluorescent labeling, real-time cell monitoring and photothermal therapy. Researchers have modified IR-820 with different biochemical molecules to enhance its fluorescence and photothermal properties, multiple types of IR-820 fluorescent nanoparticles have been prepared and investigated in biomedical imaging and tumor photothermal therapy. This article has summarized the applications of the synthesized IR-820 nanoparticles in near-infrared fluorescence (NIRF) imaging and tumor photothermal therapy and synergistic therapy, aiming to provide a reference for the further development of NIR organic fluorescent dye IR-820 in the biomedical field and the further clinical translation.