文章信息/Info

Title:

Research Progress on Graphene Oxide Nanocomposites in Antibacterial Application

文章編號:

1674-3962(2025)02-0209-08

作者:

程則瑞; 馮永海

江蘇大學材料科學與工程學院 新材料研究院，江蘇 鎮江 212013

Author(s):

CHENG Zerui; FENG Yonghai

Institute of Advanced Materials，School of Materials Science and Engineering， Jiangsu University，Zhenjiang 212013，China

關鍵詞:

氧化石墨烯; 納米復合材料; 細菌感染; 抗生素耐藥性; 協同作用

Keywords:

graphene oxide;  nanocomposite;  bacterial infection;  antibiotic resistance;  synergistic effect

分類號:

TB332

DOI:

10.7502/j.issn.1674-3962.202303007

文獻標志碼:

A

摘要:

由于抗生素的普遍使用和濫用，細菌正在以更快的速度產生耐藥性。耐藥菌感染給公共醫療衛生提出了嚴峻的挑戰，已造成了大量的死亡和超額的醫療支出。納米技術的發展有望解決這一難題。在眾多抗菌納米材料中，氧化石墨烯因其特殊的形貌尺寸和物理化學特性而具有多元化的抗菌能力。此外，氧化石墨烯具有超高比表面積、良好的電子傳導能力和豐富的表面含氧官能團，是與其他材料復合構建多功能抗菌材料的理想平臺，可產生協同抗菌作用。綜述了氧化石墨烯及氧化石墨烯基復合抗菌納米材料研究進展，列舉了近年來報道的氧化石墨烯抗菌機制研究進展和存在的挑戰，以及常見的氧化石墨烯基復合抗菌納米材料的最新發展，分析氧化石墨烯在不同材料中對協同抗菌性能起到的關鍵作用，為開發更高效的氧化石墨烯抗菌納米材料提供新的思路。

Abstract:

With the widespread and abuse of antibiotics, the drug-resistance of bacteria are becoming much stronger and harder to be conquered. Infections caused by drug-resistant bacteria have posed a serious challenge to public healthcare, which have caused tremendous deaths and excess healthcare expenditures. The development of nanotechnology paves a new way to solve this knotty problem. Among various antimicrobial nanomaterials, graphene oxide has special morphological dimensions and physicochemical properties, which allows it with diverse antimicrobial capabilities. The features of large specific surface area, good electron conductivity and abundant oxygen-containing functional groups on the surface make graphene oxide be an ideal platform for compounding with other antimicrobial materials and acting as a synergistic antimicrobial agent with other antimicrobial nanomaterials. This paper reviews the constructions of antimicrobial nanomaterials based on graphene oxide or graphene oxide-based composite, the mechanisms of antimicrobial effect and recent controversies, as well as the latest development of graphene oxide based antimicrobial composite nanomaterials. Then, we further discuss the key role of graphene oxide in different materials for synergistic antimicrobial properties, and finally provide new ideas for the development of efficient graphene oxide based antimicrobial nanomaterials.