文章信息/Info

Title:

Additive Manufacturing of Biodegradable Magnesium Alloy Customized Bone Implants

文章編號:

1674-3962(2024)11-0972-09

作者:

徐皓璟; 尹浜兆; 彭勃; 劉金戈; 田耘; 鄭玉峰; 溫鵬

1. 清華大學 清潔高效透平動力裝備全國重點實驗室，北京 100084 2. 清華大學機械工程系，北京 100084 3. 清華大學航天航空學院，北京 100084 4.北京大學第三醫院 骨科，北京 100191 5.北京大學材料科學與工程學院，北京 100871

Author(s):

XU Haojing;  YIN Bangzhao;  PENG Bo;  LIU Jinge;  TIAN Yun;  ZHENG Yufeng;  WEN Peng

1. State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Beijing, 100084, China 2. Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China 3. School of Aerospace Engineering, Tsinghua University, Beijing 10084, China et al.

關鍵詞:

鎂合金骨植入物; 增材制造; 成分調控; 結構設計; 后處理

Keywords:

magnesium alloy bone implant;  additive manufacturing;  component control;  structural design;  postprocessing

分類號:

R318.08；TG146.22

DOI:

10.7502/j.issn.1674-3962.202404037

文獻標志碼:

A

摘要:

隨著老年人口數量的增加，骨科疾病的發生率持續上升，社會對骨植入物的需求顯著提高。傳統骨植入物不可降解的特性限制了骨缺損的治療效果。鎂作為一種生物相容性優異、力學性能良好的可降解金屬，被公認為一種極具前途的新型骨植入物材料。通過增材制造技術成形定制化鎂合金骨植入物，一方面，外形精確匹配患者的骨缺損外形，另一方面，內部的多孔結構利于新骨長入。然而現階段增材制造鎂合金骨植入物存在降解周期與骨愈合周期不匹配的問題，限制了其在骨植入物領域的推廣應用。介紹了鎂合金骨植入物的增材制造工藝以及面臨的挑戰，并從成分調控、結構設計、后處理3個方面介紹了調控鎂合金植入物降解行為、力學性能和生物性能的策略。最后提出了鎂合金骨植入物的潛在研究方向和未來展望。

Abstract:

With the increase in the elderly population, the incidence of orthopedic diseases continues to rise, and there is a significantly increasing demand for bone implants. Traditional undegradable bone implants pose great limitations in bone defects treatment. Magnesium, as a degradable metal with excellent biocompatibility and mechanical properties, is recognized as a promising bone implant material. Customized magnesium alloy bone implants fabricated by additive manufacturing can accurately match the patient�餾 bone defect shape,and the internal porous structure facilitates new bone growth. However,the current additive manufacturing of magnesium alloy bone implants suffers from the mismatch between the degradation cycle and the bone healing cycle,constraining its application in the field of bone implants. This paper elucidates the additive manufacturing processes for magnesium alloy bone implants and the challenges faced, and outlines strategies for modulating their degradation behavior, mechanical characteristics and biological properties through three primary avenues: composition, structural design, and postprocessing. Finally, the potential research directions and future prospects of magnesium alloy bone implants are proposed.